Lynch Syndrome, An Inherited Syndrome

Today the speaker at Kiwanis spoke on Lynch Syndrome. I thought it was very interesting because it came up at the San Antonio Breast Cancer Symposium that I went to early in December at one of the booths. I had a discussion with someone there about it. We never have speakers on cancer. Colon cancer is caught early is a cancer that can be treated.

I learned today that colon cancer in families and endrometrial cancer in families can indicate Lynch Syndrome. I know in my family there were 6 people who had endrometrial cancer. If one is not tested they may not know that they are at risk. Some people in a family are at risk and others are not. Those at risk need to be tested periodically. Other cancers are associated with Lynch syndrome but colon and endrometrial or uterine are the biggies.

Did you know that it is important to know your families cancer history? There are red flags for hereditary cancer. Know what your relatives died from and what disease they had. Make a family history chart. This will help if you meet with a genetic counselor. These red flags  include:

colon or rectal cancer under 50

endrometrial cancer under age 50

two or more lynch syndrome cancers at any age in the same person

two or more family members with a lynch syndrome cancer, on the same side of the family one under age 50

three or more family members with lynch syndrome cancer on the same side of the family at any age

a previously identified lynch syndrome mutation in the family

breast cancer diagnosed at age 50 or younger

ovarian cancer at any age

two primary breast cancers

male breast cancer

triple negative  breast cancer

pancreatic cancer with a breast or ovarian cancer

Ashkenazi Jewish ancestry with an HBOC associted cancer

two or more relatives with breast cancer, one under 50

two or more relatives with breast cancer at any age

a previously identified BRCA mutation in the family

Lynch Syndrome:  colon, uterine (endrometrial cancer), some ovarian cancer

Lynch Syndrome cancers include colorectal, endrometrial, ovarian, gastric, ureter/renal pelvis, biliary tract, small bowel, pancreas, brain, sebaceous adenomas

HBOC Syndrome:

Risk from BRCA gene mutations, risk from a 2nd breast cancer with BRCA gene mutation, risk for ovarian cancer with a BRCA gene mutation.

HBOC cancers include breast, ovarian, and pancreatic cancers.